How difficult it will be depends upon what other software you have on your machine and its state of compatibility with the new operating system. DBA will run better on XP or 2000 but other software might run quirky or not at all.
I found a pretty elementary guide for upgrading from ME to XP here:
http://support.microsoft.com/default.aspx?scid=kb;en-us;324770 Its a Power Point presentation so I don't know if it will do you any good.
One thing you have to consider, depending on the age and condition of your machine and your future needs, is that it may make more sense to buy a new machine with XP pre-installed. That would allow you to test it while your old system is still running. If you have a problem during the upgrade, which is a real possibility, you have nothing to run on.
If you do the upgrade, do it on a weekend and backup all your data! I would back up the whole hard drive so I could just go back to square one if needed.