Wow, we use Excel for many of our metrics. Your interest probably run to sales figures, so I'll explain that a little.
One biggie is "On Time Delivery", for which I need both the SO data and the Invoice data. I pull the item class, actual ship date, promised date (ESD) requested date (ASD from the SO table) and some more identifying data and plot percent on-time shipping to both promised and requested dates. These results are broken out by classes (almost like work centers) and graphed with three years of results. Pivot tables are used to make sense of the data for graphing. The same data feeds into Pareto charts once we assign a reason to every late shipment, which is a manual operation at this point.
Another metric is breaking out a percentage of quarterly revenue coming from new products vs established items. We have added a user-defined field to items so that we can enter a date when the product went on the market. Using that field I can pull all sales by quarter and break out the sales of new products, again using pivot tables, so that we can graph percentage of sales that are coming from new products. This helps us judge the return on R&D.
There are many other ways we use Excel, including sales by territory, by class, and by customer. We also chart profit margin by class, by clinical vs. research products, and other fun P&L stuff. The options are endless